Influence of TNFα–308 and T676G TNF-RII polymorphism on response to etanercept and posibility to discontinue tretment

Results Average duration of etanercept therapy was 34.61±12.11 months. Disease subtype distribution was 6.78% systemic, 54.24% poly RFand extended-oligo, 18.64% poly RF+, 16.95% ERA and 3.38 PsA. The distribution of TNFὰ308 and T676G genotypes was not significantly different among JIA subtypes. TNFὰ308 genotypes distribution was 6.78% AA, 30.51% GG and 62.71% GA while T676G genotypes were 59.3% TT, 8.3% GG and 26.4% TG. T676G genotype polymorphism did not significantly influenced outcome. ACR Pedi 30,50,70 and 100 improvement was significantly faster and sustained in TNFὰ308 GG-genotype patients compared to GA genotype (results shown in table:*significant compared to 1 year; a-significant compared to GG). Treatment induced remission in 35.14%, had to be reintroduced due to disease worsening in 16.22%, disease was in remission under medication in 21.62% or still active in 24.32% GA patients and in 38.9%, 16.7%, 27.8% and 11.1% in GG patients, respectively. Patients with systemic or RF+ disease course were mostly treatment resistant in both genotypes. (Table 1)